Protein Details: Potassium voltage-gated channel subfamily C member 3

Protein ID

ICDB_Pro_1058

Protein Name

Potassium voltage-gated channel subfamily C member 3

Gene Name

Kcnc3

Organism

Mus musculus (Mouse)

Length

769 amino acids

AlphaFoldDB

AF-Q63959-F1-model_v4.pdb

Function

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane; forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics . It plays a role in the regulation of the frequency; shape and duration of action potentials in Purkinje cells . Required for normal survival of cerebellar neurons; probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis. Required for normal motor function . Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex

Sequence

MLSSVCVWSFRGRQGTGKQQPQPVPTPQPPESSPPPLPPPQQQQCSQPGTAASPAGAPLSCGPGGRRAEPCPGLPAVAMGRHGGGGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGTDEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDSSANANANAGGAHDAGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPAGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRVTFCPDKVEFLKSSLNIIDCVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPPPPHPHHGSGGISPPPPITPPSMGVNVAGAYPPGPHTHPGLLRGGAGGLGIMGLPPLPAPGEPCPLAQEEVIETNRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKSPITPGSRGRYSRDRACFLVTDYAPSPDGSIRKGYEKSRSLSSIVGLSGVSLRLAPLATPPGSPRATRRAPPTLPSIL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected on Purkinje cells in the dentate; interposed and medial nucleus in cerebellum (PubMed:15217387; PubMed:18448641). Detected in brainstem (PubMed:18539595). Detected at calyces of Held in the auditory brain stem (at protein level) (PubMed:26997484). Isoform KV3.3B is highly enriched in the brain; particularly in the cerebellum; where its expression is confined to Purkinje cells and deep cerebellar nuclei. Isoform KV3.3A is not expressed in cerebellum.

DOI ID

10.1523/jneurosci.14-02-00511.1994; 10.1371/journal.pbio.1000112; 10.1016/0888-7543(92)90365-y; 10.1523/jneurosci.21-17-06657.2001; 10.1111/j.0953-816x.2004.03385.x; 10.1111/j.1601-183x.2005.00184.x; 10.1074/mcp.t500041-mcp200; 10.1074/jbc.m801663200; 10.1523/jneurosci.5486-07.2008; 10.1016/j.cell.2010.12.001; 10.1113/jphysiol.2013.264309; 10.1074/mcp.o113.027870; 10.1016/j.cell.2016.02.009

RefSeq

NP_032448.2